Abstract: 

Stress-related mental disorders (e.g., anxiety, depression) and chronic somatic conditions (e.g., osteoporosis, diabetes) exhibit complex, bidirectional comorbidity with significant individual variability. Maladaptive responses to acute stress serve as a critical early determinant for the progression to chronic disorders. While the neural mechanisms underlying chronic stress are well characterized, the circuits that account for individual differences in adaptation to acute stress—particularly predator stress—remain poorly understood. Stress is a dynamic homeostatic process involving the detection, evaluation, and peripheral integration of threatening stimuli. However, prevailing research has predominantly focused on central neural circuits and hormonal pathways, overlooking how peripheral organs reshape body–brain communication through specific neural circuits, cell types, and signaling molecules. To address this gap, key mechanisms require elucidation: (1) the neural circuits governing individual variability in acute stress, especially in predator stress perception and adaptation; (2) the assessment of stressor salience and value; and (3) how peripherally derived factors modulate emotional centers during acute stress.

Biography: 

中国科学院深圳先进技术研究院脑认知与脑疾病研究所项目研究员，鹏城孔雀人才，深圳神经精神调控重点实验室副主任，中国神经科学学会中枢与外周互作分会委员，长期致力恐惧、焦虑的皮层下通路解析以及情绪障碍的外周-中枢调控机制研究，已发表SCI论文21篇，其中以第一或通讯作者（含共同）发表论文12篇，包括Neuron (2019、2025、2026 )、Science Bulletin(2019)、Progress in Neurobiology(2021)、Translational Psychiatry(2025)等。围绕负性情绪相关检测设备，授权发明专利17项，成功转化一项。主持临港国家实验室、国自然面上等基金5项，承担科技创新2030——“脑科学与类脑研究”重大项目-“抑郁症的发病机制及干预机制”、国自然重点项目等，担任广东省脑发育与脑病防治学会理事，2018年获“广东省自然科学一等奖”。 2020年获“中科院脑智卓越中心青年人才激励项目。